Beilstein J. Org. Chem.2023,19, 231–244, doi:10.3762/bjoc.19.22
, metal-free and easy to perform reaction conditions. Moreover, the pyrazole C-3/5-linked amide conjugates were also synthesized via an oxidative amination of pyrazolecarbaldehydes and 2-aminopyridines using hydrogen peroxide as an oxidant.
Keywords: C–S/O bond formation; metal-free; oxidative amidation
; pyrazolecarbaldehydes; sulfur insertion; thioamides; Introduction
During the past years, the significance of pyrazole chemistry has been notably escalated which is attributed to the discovery of their amazing biological properties. Among the heterocyclic molecules, pyrazoles are considered as privileged
for the construction of biologically interesting highly diversified pyrazole-linked thioamide and amide conjugates has been developed. The pyrazole C-3/4/5-tethered thioamide conjugates were prepared via a one-pot reaction between highly diversified pyrazolecarbaldehydes, cyclic secondary amines, and
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Graphical Abstract
Figure 1:
Representative drug molecules based on pyrazole, thioamide, and amide derivatives.